When a cure is found to treat mutations, lines are drawn amongst the X-Men, led by Professor Charles Xavier, and the Brotherhood, a band of powerful mutants organized under Xavier's former ally, Magneto.

Somewhere in the wilds of northwest Canada in the early 1800s, Logan and Victor, two half-brothers with special powers grow up amid violence. Eventually they will become the near-indestructible warriors known as Wolverine and Sabretooth. William Stryker is a sinister government operative whose Weapon X program experiments keep pulling Wolverine back in. Kayla Silverfox shares a peaceful Canadian co-existence with Wolverine as he tries to drop out...

Based upon Marvel Comics' most unconventional anti-hero, the film tells the origin story of former Special Forces operative turned mercenary Wade Wilson, who, after being subjected to a rogue experiment that leaves him with accelerated healing powers, adopts the alter ego Deadpool. Armed with his new abilities and a dark, twisted sense of humor, Deadpool hunts down the man who nearly destroyed his life.