A little boy who is not ready for sleep goes on a bedtime adventure.

Jesse Bear experiences the sights, smells, sounds, and activities of Christmas, from decorations and gifts to baking and caroling.

When Ms. Frizzle, the strangest teacher in school, takes her class on a field trip to the waterworks, everyone ends up experiencing the water purification system from the inside.

Ms. Frizzle and her class explore the senses by traveling on the magic school bus in and out of an eye, ear, mouth, nose, and other parts of both human and animal bodies.

While traveling west with her family in 1850, a young girl makes a patchwork quilt chronicling the experiences of the journey and reserves a special patch for her pet hen Josefina.

On a trip to an amusement park, Jesse Bear counts things from one silly (giggle) to ten rocks, counting on up to twenty at the end of the book.

At Halloween Jesse Bear picks out a pumpkin, helps make a jack-o-lantern, works on a costume, and has fun trick-or-treating.

On a special field trip in the magic school bus, Ms. Frizzle's class goes into outer space and visits each planet in the solar system.

Ms. Frizzle and her tour group are transported to ancient Egypt, where they learn about the pyramids, mummification, flooding of the Nile, and other aspects of life in Egypt long ago.

The children in senorita Carola's class learn about dinosaurs when the Magic School Bus travels to fossil country.