A very successful stand-up comedian, George learns that he has less than a year to live. Ira, who is a struggling up-and-coming comedian works at a deli. One night the two perform at the same club, and George decides to make Ira his best friend. This lopsided relationship gradually takes on aspects of true friendship as Ira forces George to try to reconnect with the people in his life, including his ex-girlfriend Laura. Bonus material included.

40-year-old Andy Stitzer has a cushy job stamping invoices at an electronics superstore, a nice apartment that includes a collection of action figures and comic books, good friends, a nice attitude. But at 40, Andy is still a virgin. His friends think he's a bit of an oddball, but they consider it their duty to help Andy out of his dire situation and decide to go to great lengths to help him. But nothing proves effective enough to lure their friend...