Brash adventurer Peter Quill finds himself the object of an unrelenting bounty hunt after stealing a mysterious orb coveted by Ronan, a powerful villain with ambitions that threaten the entire universe. To evade Ronan, Quill is forced into an uneasy truce with a quartet of disparate misfits. But when Quill discovers the true power of the orb and the menace it poses to the cosmos, he must do his best to rally his ragtag rivals for a last, desperate...

The grave course of events set in motion by Thanos that wiped out half the universe and fractured their ranks compels the remaining to take one final stand in the grand conclusion to twenty-two films.